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One is that the loss of a neuroprotective effect of UA when it is reduced below normal is not necessarily modelled by comparing serum levels in unaffected subjects with the hyperuricemia associated with gout

10.1021/acs.jafc.8b07313 418 SunJ.PengS.YangQ.YangJ.DaiY.XingL

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Schuh C, Wimmer I, Hametner S, Haider L, Dam A-MM, Liblau RS, et al