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Figure 2 There is also now ample evidence demonstrating that insulin reaching the liver via the portal system plays an important role in making the liver more GH sensitive to IGF-I generation (41, 42)

Some members of the diverse glutathione transferase (GST) enzyme family have GSH-dependent thiol transferase activity and participate in the recycling of antioxidants (ascorbate, flavonoids, quinones), while other isoenzymes, due to their S -transferase activity, are involved in the detoxification mechanisms using GSH as co-substrate

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This state may be secondary to a persisting stressor, such as a redox imbalance (251), persistent infection (201, 251), injury (201), insufficient nutrients (201), cold temperatures (201), or it could be due to a defect in the switch that turns off this protective state (251)

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