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Topical applications also face absorption challenges, affecting only superficial skin layers rather than providing systemic benefits

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However, the delayed gastric emptying effect may affect the absorption of some oral medicines, including oral contraceptives

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dulaglutide) comparisons among 125,336 adults with type 2 diabetes initiating a GLP-1 RA and found no difference in the rate of sight-threatening diabetic retinopathy between the different GLP-1 RA agents