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Increased oxidation, impaired GSSG reduction, limited NADPH regeneration, reduced synthesis, and preanalytical artifacts can produce similar changes

Cells 9 , 706 (2020)

[17] as well as prior observations from our center [19, 20]

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Ten-eleven Translocation (TET) enzymes converts methylcytosine (m 5 C) to hydroxymethylcytosine (hmC), which is not recognized by Dnmt1, it is believed to exclude maintenance methylation allowing for passive demethylation, and it is an intermediate in the active conversion of m 5 C to cytosine (C) 27