glp-1 for heart health The Benefits of Therapy: Beyond Weight Loss The cardiovascular effects of GLP-1

Over multiple weeks, notice how the troughs get progressively higher

doi: 10.1095/biolreprod.115.137539 164 SunZLiPWangXLaiSQiuHChenZet al

Hepatic histopathology (Fig.4-A, B) showed that both semaglutide and tirzepatide significantly reduced the non-alcoholic fatty liver disease activity score (NAS) by decreasing steatosis and cell ballooning, compared to the non-restricted diet model group

If it involves immune dysregulation, then immunomodulation deserves investigation

PMID 1478791

In particular, ECL1 and ECL3, which were disordered in the previous TMD structure, are now ordered and form a -helical conformation reminiscent of the peptide-bound GLP-1R structures