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The side effect profile at the 12mg dose includes nausea (28% of participants), diarrhea (23%), constipation (17%), and vomiting (12%)

10.3389/fphys.2014.00159 76 KenyonS

When looking at the entire group, the weight change after 14 weeks was minimal in the placebo group (+0.5%), but the TE groups showed weight reductions of -0.5%, -0.9%, -1.32%, and -2.32% for different doses of TE

Physiol Rep 7(22):e14276 Pugh JN, Sparks AS, Doran DA, Fleming SC, Langan-Evans C, Kirk B et al (2019) Four weeks of probiotic supplementation reduces GI symptoms during a marathon race

If the shunt is significant, there is progressive damage to the pulmonary vasculature and gradual development of irreversible pulmonary hypertension

furthermore showed that the Mediterranean diet may improve ovarian morphology and ovarian function in women of reproductive age (33)