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While organ-specific nitrite was not affected, the global circulating reduction in nitrite indicates endothelial dysfunction as described previously 22

Given that the upper limit of the two-sided 95% CI for the estimated difference in A1C between both doses of SEM and SIT was less than the pre-specified 0.3% margin, NI of both doses of SEM treatment to SIT at week 56 was concluded in SUSTAIN-2

Fernandez-Miranda C, Martinez Prieto M, et al