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Current Pharmaceutical Design , 2020 In various studies, BPC-157 was observed to: Accelerate healing of muscle, tendon, ligament, nerve, and gut tissue Reduce inflammation, fibrosis, and oxidative stress Protect organ systems (gut, liver, brain) under chemical or surgical stress Stabilize blood vessels and prevent internal bleeding in injury models Importantly, these effects occurred without toxicity , even when administered in high or repeated doses

For example, one study found that after taking 1,000 mcg of oral vitamin B12, only about 1.3% (13 mcg) is absorbed into the bloodstream

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In addition, mitochondria lack more advanced repair pathways, such as nucleotide excision repair and homologous recombination, which makes mtDNA particularly susceptible to the accumulation of mutations [35], which leads to a higher rate of damaged mtDNA in mitochondria and further aggravates oocyte damage

10.1021/acscentsci.7b00420 ACS Cent Sci

Longo, G.V