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The review found moderate-certainty evidence that tramadol users were more than twice as likely to experience a serious adverse event, such as cardiac problems or newly diagnosed cancers, though the researchers noted the short duration of the trials (mostly under 16 weeks) meant a causal link to cancer couldnt be confirmed
While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort
Brinkmann, U
Its preventive potential appears to be related to improving the function of the endothelium (the layer of cells that help blood vessels relax)
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