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SIRT1 activation restores autophagy by deacetylating FOXO3a and upregulating autophagy-related genes, including Atg5 and LC3-II, enhancing cellular stress adaptability and improving insulin sensitivity

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Aside from this rather direct link, inflammation can also cause an increase in weight with Hashimotos by its influence on essential fat-regulating hormones insulin and leptin

2003;(1):CD002147