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However, resistance to potent anti-androgen drugs like enzalutamide and abiraterone acetate poses a growing challenge in advanced PCa treatment (Kafka et al., 2020)

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Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively