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Consistently, the present study revealed that TGF-1 + IL-1 significantly activated NLRP3 inflammasome and induced fibroblast activation, but did not affect the protein level of GSDMD-NT

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Figure 5 The SURMOUNT-1 study was a clinical trial of 72 weeks performed in 2539 obese patients without T2D that were randomized in four arms with placebo or TZP at the dose of 5mg,10 mg or 15 mg (72)