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References: Murcia A, Jimnez-Monrea AMl, Gonzalez J, Martnez-Tom M(2020)

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p53 orchestrates cancer metabolism: unveiling strategies to reverse the Warburg effect

On the other hand, IGFBP-3 undergoes augmented proteolysis on diabetic patients which results in a sudden rise of free IGF-1 concentrations [257, 258]