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Important safety considerations include: Pancreatitis risk : If you develop severe, persistent abdominal pain that may radiate to your back, with or without vomiting, stop taking the medication and seek urgent medical attention Gallbladder disease : Sudden pain in the upper right abdomen, fever, or yellowing of the skin/eyes requires urgent medical review GLP-1 medications are not recommended in people with severe gastrointestinal disease, including severe gastroparesis [10] [11] Clinical considerations include: Starting with the lowest available dose and titrating slowly Monitoring symptom patterns carefully during initiation Distinguishing between temporary side effects (which often lessen over weeks) and persistent symptom changes Adjusting dietary intake, particularly meal size and composition Most gastrointestinal side effects of GLP-1 medications are dose-dependent and tend to diminish over time as the body adapts

This article explains what Wegovy and Mounjaro are, why someone might consider switching, who may be eligible, and how a New Zealand doctor can help manage the transition safely

Head-to-head evidence SURPASS-2

doi: 10.1007/s00125-015-3651-3 80 HervasI.QueirozC

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