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doi: 10.1093/jas/skad341.385 31 ClementsA

Gastrointestinal side effects like nausea or constipation can reduce food intake beyond the medication's appetite-suppressing effect, sometimes accelerating early loss but potentially becoming unsustainable

Introduction The prevalence of nephrolithiasis has been increasing worldwide and about one in 17 adults suffer from kidney stones in China ( Calcium oxalate (CaOx), as the most common constituent of kidney stones, can interact with renal tubular epithelial cells and induce oxidative stress, inflammation and fibrosis, further promoting tubular cell injury ( Previous basic and clinical research has revealed that molecular hydrogen exerts multiple biological effects involving anti-oxidation, anti-inflammation, anti-fibrosis and anti-apoptosis in many diseases of different systems ( Previous studies indicated that feeding a soluble oxalate diet represents a successful mouse model of CaOx crystallization, which has the characteristics of CKD [PMID: ( Materials and Methods Animal Experiments Male ICR mice aged 67 weeks and weighed 2530 g were purchased from Shanghai Jiesijie Lab Animal Co., Ltd

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Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, et al