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Sinclairs research is focused primarily on understanding genes that fight disease and aging, with a focus on treating the major causes of death and disability

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Notably, composite dietary fiber preserved skeletal muscle mass and function and downregulated the expression of key proteolytic markers Atrogin-1 and MuRF-1

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Psychotropics including fluoxetine, tricyclics, lithium, valproate, ketamine and others are explored in relation to their effect of PKC, finding that across all drugs examined, a downregulation with chronic-but not acute-use constitutes their putative effect in ameliorating symptoms

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