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Lastly, investigating combination therapies that integrate ferroptosis inhibitors with other therapeutic strategies, such as antioxidants or anti-inflammatory agents, may provide synergistic benefits and improve treatment outcomes

doi: 10.1016/j.kint.2020.06.008 149 BlancoLPKaplanMJ

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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)