47,53,56 GSIS is a biphasic event in healthy humans: first phase insulin release lasts only a few minutes whilst the prolonged second phase sustains insulin secretion to deal with post-prandial nutrient loads
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It changes body composition gradually
The disease typically occurs without any pain and most commonly affects people ages 50 and above
Rapid weight loss, which can happen at the higher doses of GLP-1s, can come with potential drawbacks, like increased muscle loss and hair loss, so slowing it down can be a good idea for some people
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