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however, they should be reserved for inadequate weight loss despite implementing lifestyle interventions, according to the American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) 2016 clinical practice guideline

N Engl J Med 2015;373:2117-28.ArticlePubMed 37

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This discovery sparked extensive investigation into its therapeutic potential for metabolic disorders (Zander et al

The primary concern with GLP-1 therapy and MS centers on potential immune system activation or disease-modifying medication interactions, not the GLP-1 mechanism itself

If weight loss stalls at a given dose, increasing the dose may restart progress