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AtSNX1-Ch/mYongHong and MmSNX1-mYongHong were cloned into pCAMBIA1305 vector and generated by the floral dip method 63

Senescent cells can accumulate over time, affecting the function of cells around them

483,484,485 PPAR- agonists (thiazolidinediones and TZDs) used for diabetes mellitus, which enhance adipocyte lipid storage, decrease ectopic lipid accumulation and improve insulin sensitivity in liver and skeletal muscles

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Apoptosis assay Apoptosis was evaluated via DNA fragmentation using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay following a previously described protocol [54]