Antioxidant capacity is connected to the capability to neutralize superoxide and hydroxyl radicals, which helps prevent free radical that induced retinal pigment epithelium death [288]
Additionally, glutathione disulfide (GSSG) is involved in the degradation of drug delivery systems containing disulfide bonds, which allows for targeted drug release in cancer therapy
In one study, inadequate zinc intake was observed and zinc deficiency was suggested in patients with MS [27]
A recent clinical trial evaluating the supplementation of ALA (in combination with Coenzyme Q10) in Long COVID patients yielded striking results: 53.5% of the treatment group achieved a complete response on the Fatigue Severity Scale (FSS), compared to just 3.5% in the placebo control group
Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events
However, how this happens is not completely understood
