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All additions to the ACO participant list approved by CMS during the change request cycle are effective on January 1 of the next performance year ( 425.118(b)(1)(ii))

Moreover, in the CY 2023 PFS final rule (87 FR 70088 through 70090), we finalized beginning with the CY 2023 performance period/2025 MIPS payment year, that we would score administrative claims measures using performance period benchmarks ( 414.1380(b)(1)(ii)(D))

Theres also a financial reality here

This remarkable enhancement occurs through the VEGFR2 receptor pathway rather than by increasing VEGF-A ligand levels directly

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The comparison of peptides versus other treatments helps contextualize these differences