Indeed, transgenic mice given the human presenilin-1 (PS1) genewhich encodes one of the two subunits of -secretasewith one missense mutation (Val97Leu, PS1V97L) formed abundant A oligomers (Zhang et al., 2014), produced cognitive deficits, and exhibited cellular oxidative stress markers (Tian et al., 2019
There is increasing evidence that these models share pathologic and biochemical characteristics seen in the more traditional models of focal and diffuse TBI, including hemorrhage, diffuse axonal injury, cortical and subcortical cell injury, metabolic disturbances/energy failure, inflammation, and oxidative stress
[DOI] [PMC free article] [PubMed] [Google Scholar] Alscher R.G
10.1038/s41586-023-06269-0 68 MaJ.YuP.MaS.LiJ.WangZ.HuK.et al (2024)
To nourish the skin cells and the skin will be white naturally without making the sensitive to the sun
In the immune system, adequate glutathione supports balanced immune function and may show anti-inflammatory properties