In contrast to human tissue and cultured cells, it has been demonstrated that Nrf2 activity is consistently elevated in the spinal cord of SOD1 G93A rodent models of ALS, and the increase of Nrf2, thioredoxin, HSP-70, HO1, NQO1, GCLC, and GCLM protein levels follows disease progression in the lumbar spinal cord but not cortex [264, 265]
Whether the hyperprolactinemia, amenorrhea, and galactorrhea were secondary to the hypothyroidism or were independent problems was at first unclear
doi: 10.1016/j.kint.2023.10.018 277
Domain I helices are shown in dark blue and beta strands are shown in red
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