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Molecules 26:2059 Kakde D, Jain D, Shrivastava V, Kakde R, Patil A (2011) Cancer therapeutics-opportunities, challenges and advances in drug delivery

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The utilization of in vitro models becomes an even more appealing option if we take into account the growing ethical constraints on the use of animals and human samples in biomedical research

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Another study revealed that the oral administration of Polygonum cuspidatum aqueous extract in rats with resected exorbital lacrimal glands restored tear volume and Mucin4 (MUC4) expression by mitigating corneal abnormality and the release of inflammatory cytokines [76]