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Symptoms of dyspepsia, nausea, vomiting, bloating, diarrhea, and constipation stand out among the gastrointestinal adverse effects described.514 The presence of gastrointestinal adverse effects associated with antidiabetics has an overall impact on the patient with diabetes, given that they can increase the need for medical attention, affect quality of life due to the symptoms they trigger, and modify therapeutic regimens

The two cysteine residues form a disulfide bond, creating a cyclic structure that enhances stability

Common side effects include nausea, vomiting, diarrhoea, and constipation, particularly during the initial titration period

222 In preclinical research, a constituent from yerba mate reduced thrombin activation and venous thrombosis

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