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2 Materials and methods 2.1 Materials and reagents L-Carnosine, lipopolysaccharides, and papain were purchased from MCE (New Jersey, United States)

These three compounds are known to be major constituents of PJE [285]

Importantly, the retention time and integral of the peak corresponding to Ru(II)-OH remained unchanged, suggestive that this is a catalytic process (Supplementary Fig

These include oral drugs or biologic injections that target specific parts of the immune system

However, repeated or frequent injections may pose risks, including chondrotoxicity and acceleration of cartilage degeneration

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