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There are currently no effective treatments for ALS and therapy is limited to symptomatic and palliative treatment (Miller et al., 2012) and edaravone (Rothstein, 2017) are the only approved pharmacological therapies that increase the survival rate by 23 months (Dorst et al., 2017

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Thus, the combined administration of hepsin with NAC optimized the therapeutic outcome, enhancing effectiveness beyond what was achievable with NAC alone

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