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Autophagy The impairment of autophagy and the clearance of accumulated, unwanted proteins play crucial roles in the development of neurodegeneration

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Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans

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The peptide has a short half-life of approximately 15 minutes in vitro due to degradation by aminopeptidase-like enzymes, though research suggests it may be more stable in vivo due to binding interactions with carrier molecules in circulation