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[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Lim SK

According to the Global Burden of Disease 2021 study, IS ranks as the second leading cause of death worldwide and remains a major cause of long-term disability ( Disruption of the bloodbrain barrier (BBB) is a key pathological feature of IS, primarily caused by degradation of tight junction (TJ) proteins and increased transcytosis, leading to vascular hyperpermeability ( The BBB is a specialized neurovascular interface that regulates molecular and ionic exchange between the systemic circulation and the central nervous system (CNS), thereby maintaining cerebral homeostasis ( Circadian rhythms are endogenous 24-h cycles regulated by the suprachiasmatic nucleus (SCN) in the hypothalamus, which synchronizes peripheral oscillators across mammalian tissues ( Circadian rhythms influence the onset, progression, and clinical outcomes of IS by regulating diurnal blood pressure patterns, vascular tone, and platelet activity ( 2 (PGD 2 ) are expressed in the central nervous system and may influence stroke pathogenesis by altering BBB circadian dynamics ( 2 Circadian rhythms directly regulate BBB damage and repair following IS 2.1 Circadian rhythms directly regulate endothelial cell function Endothelial cells (ECs) of the BBB display circadian rhythmicity and contain an intrinsic circadian regulatory system (56)

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Santos M et al

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