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In addition, a genetically determined increased expression of TNFAIP3 (A20) (rs6927172) 27 was associated with nonresponse among patients with IBD

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*The GHRH-GH-IGF-1 Axis: The brains hypothalamus signals via growth hormone releasing hormone (GHRH) to the pituitary under the brain to release growth hormone (GH), which has direct effects on muscle, bone, and fat, and stimulates the release of insulin-like growth factor-1 (IGF-1)

Thus, it is often referred to as the sleep hormone. Additionally, melatonin has antioxidant properties and modulates other physiological functions, such as blood pressure and body temperature [3, 4]

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A 2025 review by Jozwiak and colleagues surveys the peptides multifunctionality and possible medical applications (PMC11859134), and is a useful map of what has and has not been established