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A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

The suggestion is that reduced GR activity and therefore less 'reduced glutathione' may be implicated in Irritable Bowel Syndrome - possibly because it has less defenses against free radicals, the cause of oxidative stress

Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

Barl B, Akhov L, Dunlop D, et al (2003) Flavonoid content and composition in leaves and berries of sea buckthorn (Hippophae spp.) of different origin

Servais A, Janssen MCH, Blakey H, Greco M, Lemoine S, Martin-Moreno PL, Game D, Levtchenko E, Lipkin G

Research Square Preprint2023 Sep 12