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Endometrial carcinoma in vitro chemosensitivity testing of single and combination chemotherapy regimens using the novel microculture kinetic apoptosis assay: implications for endometrial cancer treatment

By its upstream action of inhibiting lipid peroxidation, GPX4 can indirectly but effectively reduce the expression levels of these destructive enzymes, thereby delaying or preventing ECM breakdown (El-Bikai et al., 2010)