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However, synthetic LA is a racemic mixture of R and S isoforms, where S-LA can prevent the polymerization of R-LA to enhance its bioavailability (Shay et al., 2009)

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10.1017/S1461145707008401 Int J Neuropsychopharmacol

Schoeneberg et al

Several other multi-agonists capable of co-agonism of the GLP-1 and glucagon receptors are currently in development including BI 456906 (Boehringer Ingelheim), LY3305677 (Lilly) LY4347943 (Lilly), JNJ-54729518 (J&J), HM15211 (Hanmi), NNC9204-1706 (Novo), Alt-801 (Altimmune) and G3215 (Imperial College/Zihipp Ltd.) see Table 1