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In fact, less than 20 % of vitamin C that we consume whether through food or conventional supplements is bio-available for uptake by the cells and that is where it must reach

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Results: MTX altered the concentration of 31 out of 70 metabolites analyzed, suggesting inhibition of the glycine cleavage system, the pentose phosphate pathway, purine and pyrimidine synthesis, phospholipid metabolism, and bile acid uptake

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Washington, D.C.: Wiley-Blackwell