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GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)

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Semaglutide, is GLP-1 receptor agonist, provides a synthetic version of the human GLP-1 hormone with 94% sequence homology

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