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This work is central to how organs develop, repair themselves, or respond to stress

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Met is directly converted by MATI/MATIII into SAMe, and MATI/MATIII deficiency could lead to decreased SAMe levels and its downstream products including GSH

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Glutathione is also an important storage and transport form of reduced sulfur owing to the thiol-containing Cys residue incorporated into the tripeptide and its biosynthesis is strongly dependent on the sulfur assimilatory pathway including necessary feedback inhibition mechanisms 63

Epilepsy in Biotinidase Deficiency After Biotin Treatment