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Because vitamin B 12 in supplements is not bound to protein, and because intrinsic factor (IF) is still available, the absorption of supplemental vitamin B 12 is not reduced as it is in pernicious anemia

10.1016/bs.ant.2020.01.001 141 RosenthalT

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Figure 1: Vitamin B12 absorption begins in the mouth, where chewing and saliva help release it from food