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Why Co-Agonism Opens Qualitatively Different Research Questions Hitting two receptors at once changed the questions labs could ask

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In contrast, high glucose-induced GLP-1 release was unaffected by PPAR/ inhibition, suggesting that C3G-induced PG gene transcription to increase GLP-1 levels in STC-1 cells was specifically mediated through the PPAR/--catenin-TCF signaling pathway