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While the myriad changes that occur with immunosenescence are complex and not fully understood, in relation to AD/ADRD, a key dysfunction is impaired chemotaxis (cell movement in response to a chemical stimulus) and phagocytic function of microglia in the brain and peripheral macrophages (Liu et al., 2023

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For GC/MS analysis, samples were derived using bistrimethyl-silyl-triflouroacetamide (BSTFA), and analysed on a Thermo-Finnigan Trace DSQ fast-scanning single-quadrupole mass spectrometer using electron impact ionisation

Similarly, dietary interventions such as ketogenic and fasting-mimicking diets show metabolic and immunologic benefits in mice, but their applicability and sustainability in human patients warrant rigorous clinical assessment

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