Possible Mechanisms Behind the Conflicting Results The mixed results on GLP-1 receptor agonists and mental health could be due to several things
Sleep Health
Some individuals may experience mild digestive adjustment initially
These occur in a significant proportion of patients, particularly during dose escalation
Key Timeline Dates: August 2, 2023: First lawsuit filed by Jaclyn Bjorklund February 2024: MDL 3094 created, cases consolidated July 3, 2024: Mass Eye & Ear NAION study published December 2024: 1,300 pending cases January 2026: 3,063 pending cases (more than doubled) May 14, 2025: Critical hearing scheduled on admissibility of expert causation testimony Settlement Projections (Not Actual Payouts) Attorney Estimates No Settlements Finalized Important Disclaimer: No global settlements have been announced as of January 2026
In addition, MT-II has raised concerns about melanoma risk, as a case study involving a month of peptide use combined with intensive sunbed tanning procedures led to the development of this type of skin cancer