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Researchers do not recommend methionine because it causes an increase in homocysteine levels [99]

Its concentration increases along a longitudinal gradient throughout the gastrointestinal tract, peaking in L cells of the colonic and rectal mucosa ( 2.2 Synergistic interaction between PYY and GLP-1 PYY and glucagon-like peptide-1 (GLP-1) are both predominantly co-secreted from intestinal L-cells in response to nutrient ingestion, forming a key hormonal duo in the gut-brain metabolic axis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Koopmans SJ, Frolich M, Gribnau EH, Westendorp RG, DeFronzo RA