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CTAD taskforce: genetic therapies in Alzheimer's disease
doi:10.1021/acs.jmedchem.1c00565 Eren S, Tonin G, Jurii Eren D, Klen J
ALCAR crosses the blood-brain barrier more readily than LCAR, achieving better central nervous system penetration.[1][2] In elderly patients specifically, LCAR absorption appears impaired due to decreased active transport, making ALCAR the more effective option in this population.[1] However, recent pharmacokinetic data shows that ALCAR has significantly lower overall bioavailability than LCAR (7.7-fold lower area under the curve), with most absorbed ALCAR being converted to LCAR before reaching systemic circulation.[3][4] For neurological disorders , ALCAR demonstrates distinct advantages
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For example, there are natural alpha-tocopherol derivatives where the derivatives are added through synthetic procedures
& Voet, J
