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After fatty infiltration of the pancreas, beta ()-cell dysfunction was tightly connected to the presence and severity of NAFLD creating a vicious-cycle of a feed-forward effect [19, 20]

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

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How can we prevent adverse cardiovascular events in this growing population