can you switch from semaglutide to tirzepatide for weight loss vs Tirzepatide: Which GLP-1 Wins Loss? Switching between weight-loss medications -

Semaglutide, a glucagon-like peptide receptor agonist (GLP- 1 RA), was shown in STEP 1 to produce mean weight reduction from baseline to week 68 of 14.9% for semaglutide versus 2.4% for placebo, by treatment-policy or treatment-regimen estimand which is reported throughout this manuscript, except where noted [1]

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Similarly, a meta-analysis of tirzepatide-only data reported no excess risk for thyroid cancer compared to control groups

Together with Daniel Drucker's paper it shows that neither Semaglutide nor Tirzepatide are good drugs to treat CNS diseases, as they do not cross the blood-brain barrier in meaningful quantities

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