Mycobacterium smegmatis (MS) was used as the expression system to produce active soluble recombinant PLC from Mtb that was expressed at very low levels, therefore the biochemical properties and the substrate specificity of Mtbs PLCs are yet to be determined (Johansen et al., 1996)
But lets face it that was true even before COVID-19 swept through our nation what with juggling work, family life, exercise, socialising, and trying to squeeze in some good old-fashioned downtime
Study: Anti-obesity medication use sparks effort-based sanctions and social penalties
Aortic rings were then pre-contracted with 3 M PE
Identification of metabolites with antibacterial activities by analyzing the FTIR spectra of microalgae
The underlying logic is the same: match the delivery vehicle to the compounds pharmacokinetic profile and the studys specific endpoints