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Nrf2 is the principal transcription factor in charge of protecting cells from oxidative stress through the regulation of cytoprotective genes, including the antioxidant GSH pathway, that controls GSH homeostasis by affecting de novo synthesis
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The rationale is mechanistic extrapolation, not demonstrated synergy
doi: 10.1074/jbc.M109.027433 7 KamisakoTKobayashiYTakeuchiKIshiharaTHiguchiKTanakaYet al
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