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After a 5-hour fast, mice were administered water or sitagliptin at 14 g/mouse (gut-selective dose) or 10 mg/kg (systemic DPP-4 inhibition) by gavage

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Clinical trials show participants achieve an average weight loss of 15% of their body weight over 68 weeks, but the pace of loss varies significantly week to week

Rare cases of acute kidney injury have been reported in GLP-1 users, usually linked to severe dehydration from nausea or vomiting rather than direct drug toxicity