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In real reproductive biology it is shorthand for three different things, and each one responds to a different lever

The investigators attributed the angiogenic effect to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the Aktendothelial nitric oxide synthase (eNOS) signaling pathway

Journal of Neurotrauma 22(9):1003-1010

This can cause shear stress and damage the molecules

Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds.. Regulatory toxicology and pharmacology : RTP.Study breakdown PubMed 9RPEP-02350Chang, Chung-Hsun et al

Surprisingly, yes