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Also, they must abide by the 0.01% Zero Tolerance limit, according to the VC 23136

(March 2019)

Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)

In addition to the excellent therapeutic effect on diabetic cardiomyopathy, sinapic acid also ameliorated the expression of apoptosis-related proteins in STZ-induced Wistar rats diabetic kidneys via Nrf2/HO-1 mediated pathways [154]

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